EOX

EOX is the name of a combination of chemotherapy drugs used to treat stomach cancer and gastro oesophageal cancer. It is made up of the drugs

• Epirubicin
• Oxaliplatin
• Capecitabine (Xeloda)

The links above take you to more information about the individual side effects of each drug.

The side effects of a combination of drugs are usually a mixture of those of each drug. The combination may increase or decrease your chance of getting each side effect or it may change the severity. The side effects associated with EOX are listed below. You can use the underlined links to find out more about each one. For general information, see our cancer drugs side effects section.

You usually have EOX chemotherapy as cycles of treatment. Each cycle of treatment lasts 3 weeks. Depending on your needs, you may have up to 8 cycles, taking around 6 months in total.

You have epirubicin and oxaliplatin every 3 weeks into your bloodstream (intravenously). You may have them through a central line, a portacath or a PICC line. These are long, plastic tubes that give the drugs directly into a large vein in your chest. You have the tube put in just before your course of treatment starts and it stays in place as long as you need it.

You have each cycle of treatment in the following way.

On the first day you have epirubicin as an injection and oxaliplatin as a drip (an infusion) over a couple of hours. Epirubicin is a red liquid. You also start taking capecitabine every day. Capecitabine is a peach coloured tablet. You take the tablets twice a day - one dose in the morning and one in the evening. You swallow them whole with plenty of water after food. The body changes capecitabine into the chemotherapy drug fluorouracil.

Your next cycle of treatment then starts 3 weeks later when you have the epirubicin and oxaliplatin again.

More than 10 in every 100 people have one or more of the side effects listed below.

Temporary drop in the number of blood cells made by the bone marrow, causing

• Increased risk of getting an infection from a drop in white blood cells - it is harder to fight infections and you can become very ill. You may have headaches, aching muscles, a cough, sore throat, pain passing urine or feel cold and shivery. 
• Tiredness and breathlessness due to a drop in red blood cells (anaemia) - you may need a blood transfusion
• Bruising more easily due to a drop in platelets - you may have nosebleeds, bleeding gums after brushing your teeth, or lots of tiny red spots or bruises on your arms or legs (known as petechia).

Some of these side effects can be life threatening, particularly infections. You should contact your doctor if you have any of these side effects. Your doctor will check your blood counts regularly to see how well your bone marrow is working.

Other common side effects include

• Tiredness during and after treatment – most people find their energy levels are back to normal within 6 months to a year
• Epirubicin can turn your urine pink or red for about one day after treatment – this is nothing to worry about
• Feeling or being sick can be severe with epirubicin and oxaliplatin but is usually well controlled with anti sickness drugs - if your sickness is not controlled tell your doctor as they can change your anti sickness drugs to others that work better for you
• Diarrhoea in 2 out of 3 people (more than 60%) – drink plenty of fluid and tell your doctor immediately if diarrhoea becomes severe, or if it continues for more than 3 days
• A sore mouth
• Numbness or tingling in fingers and toes affects up to 8 out of 10 people (80%) and can cause difficulty with fiddly things such as doing up buttons - it starts within a few days or weeks and usually goes within a few months of finishing treatment
• Some people develop soreness, redness and peeling on the palms of the hands and soles of the feet (palmar – plantar syndrome) which may cause tingling, numbness, pain and dryness
• Hair loss - you may have complete hair loss but the hair will grow back once the treatment ends
• Skin changes including rashes (which may be itchy), darker skin, sensitivity to sunlight, and redness or soreness in areas of skin previously treated with radiotherapy
• These drugs may have a harmful effect on a developing baby – do talk to your doctor about contraception before having treatment if there is any chance that you or your partner could become pregnant
• Women may stop having periods (amenorrhoea) but this may be temporary
• Loss of fertility – we don’t know exactly how this drug affects fertility so do talk with your doctor before starting treatment if this is important to you
• Loss of appetite

Between 1 and 10 in every 100 people have one or more of these.

• Difficulty swallowing or breathing happens in 1 or 2 people out of every 100 (1 to 2%) – it is usually triggered by cold in the first 5 days after you have the drug and clears up on its own. Tell your doctor if you have this side effect.
• Inflammation around the drip site – if you notice any signs of redness, swelling or leaking at your drip site, tell your chemotherapy nurse immediately
• Gritty eyes, blurred vision or watery eyes from increased production of tears
• Loss of appetite
• You may have ringing in the ears (tinnitus) which nearly always gets better on its own
• Loss of taste or a metallic taste in your mouth
• Some people have an allergic reaction while having EOX treatment, usually at the first or second treatment – let your treatment team know immediately if you have any skin rashes, itching, dizziness, headaches, shortness of breath, anxiety, shivering, or if you feel hot, go red in the face, or have a sudden need to pass urine.

Fewer than 1 in 100 people have these.

• Damage to heart muscle from epirubicin, which is usually temporary but for a small number of people may be permanent – your doctor will check your heart before and after your treatment
• Swelling of hands and feet due to fluid build up
• Confusion or unsteadiness

You won't get all these side effects. Any that you have may be mild. A side effect may get worse through your course of treatment. Or you may have more side effects as the course goes on. This depends on

• How many times you've had a drug before
• Your general health
• How much of the drug you have (the dose)
• Other drugs you are having

Talk to your doctor, pharmacist or nurse about all your side effects so they can help you manage them. Your nurse will have given you a contact number. You can ring if you have any questions or problems. They can give you advice or reassure you. If in doubt, call them.

Tell your doctor about any other medicines you are taking, including vitamins, herbal supplements and other over the counter remedies – some drugs can react together.

You should not have immunisations with live vaccines while you are having chemotherapy or for at least 6 months afterwards. In the UK, these include rubella, mumps, measles (usually given together as MMR), BCG and yellow fever. You can have other vaccines, but they may not give you as much protection as usual until your immune system has fully recovered from your chemotherapy.

It is safe for you to be in contact with other people who've had live vaccines as injections. There can be problems with oral vaccines, but not many people in the UK have oral vaccines now. So there is usually no problem in being with any baby or child who has recently had any vaccination in the UK. If you live abroad, you might need to make sure that you aren't in contact with anyone who has had oral polio or oral typhoid vaccination recently.