A study to find out more about the causes of some types of lymphoma and chronic leukaemia

This study is looking at blood, bone marrow and tissue samples from people with white blood cell (lymphocyte) disorders, to discover more about the causes and possible future treatments.

Conditions where lymphocytes have become cancerous are called lymphoproliferative disorders and include

Chronic lymphocytic leukaemia (CLL)
Mantle cell lymphoma
Follicular lymphoma
Hairy cell leukaemia
Splenic lymphoma with villous lymphocytes

Doctors want to find out more about these cancerous cells. In this study you will give samples of blood and any extra bone marrow or tissue you may have removed during routine procedures. Researchers will look at any abnormal cells. They are looking for genes, including a particular gene called the ‘immunoglobulin gene’ that help the cancer cell to survive.

The aim of this study is to understand more about how changes to certain genes, proteins and sugars could affect how these diseases develop. This may help develop new treatments for these conditions in future.

You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.

Recruitment

Start 01/08/2002

End 31/12/2013

Phase

Other

Who can enter

You can enter this study if you have any of the following cancers

Chronic lymphocytic leukaemia (CLL)
Mantle cell lymphoma
Follicular lymphoma
Hairy cell leukaemia
Splenic lymphoma with villous lymphocytes (SLVL)

Trial design

Everyone taking part will have a study blood test at the time they are diagnosed, and when you come to the hospital for your yearly routine follow up visit, so the team can monitor changes in the blood cells. The team will also ask permission to study any stored samples of bone marrow or lymphatic tissue that you have had removed as part of your routine treatment. The study team will also look at your medical notes to see how you are getting on.