A trial looking at zalutumumab with radiotherapy for head and neck cancer (GEN207)

This trial was looking at zalutumumab with radiotherapy for cancer of the mouth or cancer of the voice box (larynx) that is locally advanced.

Doctors often treat locally advanced cancer of the mouth and larynx with chemotherapy and radiotherapy together. They most often use platinum chemotherapy drugs. But some people are not able to have platinum drugs.

Zalutumumab is a type of biological therapy called a monoclonal antibody. We knew from laboratory studies that zalutumumab may stop or slow down the growth of cancer cells.

The aim of this trial was to find the maximum dose of zalutumumab to use with radiotherapy.